The Science and Justice Research Center at the University of California, Santa Cruz, is a globally unique endeavor that innovates experimental civic spaces and collaborative research practices for exploring today’s most pressing challenges. Biomedical innovation, species extinction, big data and other contemporary matters of concern pose questions that cross multiple intellectual and institutional lines. Science & Justice generates collaborative modes of inquiry and empirically rigorous research that can address these enormous challenges and support a diversity of livable technoscientific worlds. The Center is home to the Science and Justice Working Group, graduate training programs and sponsored research projects. The initiative builds on the UCSC campus’ historic commitments to social justice and strengths in science studies and interdisciplinary research.