Aug 19, 2012 | Modelling pigs and humans: Exploring the practices of models across sciences

Wednesday October 19, 2011

Engineering 2, Room 599

PhD Fellow Vibeke Pihl, Medical Centre for Science and Technology Studies, Department of Public Health, University of Copenhagen.

Vibeke Pihl’s research addresses how connections between humans and animals are shaped in contemporary biomedical research on human health. During an ethnographic multi-sited fieldwork, Vibeke has followed a group of Danish biomedical researchers working to establish a pig model for human obesity surgery. In biomedicine, the pig is increasingly established as a preferred model organism in biomedical research on human obesity due to an argued biological resemblance between pigs and human anatomy and physiology. The topic of the SJWG event concerns an analysis of how the use of pigs as models for humans does not rest solely on biological connections, but requires social, moral, economical and cultural connections to support the choice of the pig as the appropriate model for obese human bodies. In addition, the presentation will address how models are practised in biomedical science and social science. Drawing upon fieldwork, the presentation will focus on how the analysis of the biomedical researchers’ establishment of a pig model prompt a simultaneous crafting of a social scientific model of human-animal relations. Vibeke asks which connections between humans and pigs are included and excluded in the research practices of biomedical scientists’ and the practices of social scientists like her own. With this presentation, Vibeke wants to provide an opening for a stronger mutual engagement between researchers across sciences working with animals as models of humans.

Fall 2012 | Science & Justice Working Meetings

John Kadvany: A Very Short Introduction to Risk

Wednesday, October 5, at our normal time and place (Eng 2 599. 4:15-6:15).

John Kadvany will join us to discuss the concept of risk. Oxford University Press recently published John’s book on risk, entitled Risk: A Very Short Introduction. Given that so many of us in the group are interested in thinking well about risk–whether in the context of genomics or the climate or engineering design–we are particularly pleased to have John kick the year off.

Click here for an introduction to some of John’s ideas about risk.

Kadvany often works on project teams organized by an engineering company in charge of a large public works project. His role is to design and help implement a decision process in which engineers, external stakeholders, lawyers and regulators work their collective way through multiple competing options in an efficient, democratic and cooperative manner. He will design an analytical frameworkthat’s useful all around including the measurement techniques which can be used to accommodate relevant models, data, and professional or lay judgment of various qualities. Often these processes lead to a group “opinion survey”, a combined technical-policy document which summarizes stakeholder perspectives. His methods combine the analytical techniques of multiple values decision analysis with the approaches developed in the last two decades through the public participation movement.

Aug 18, 2012 | The Black Panther Party and The Fight Against Medical Discrimination

Alondra Nelson (Colombia, Sociology)

Monday March 12, 2012

College 8, 301

Time: 12:30-2:00PM

Between its founding in 1966 and its formal end in 1980, the Black Panther Party blazed a distinctive trail in American political culture. The Black Panthers are most often remembered for their revolutionary rhetoric and militant action. Here Alondra Nelson deftly recovers an indispensable but lesser-known aspect of the organization’s broader struggle for social justice: health care.

The Black Panther Party’s health activism– its network of free health clinics, its campaign to raise awareness about genetic disease, and its challenges to medical discrimination–was an expression of its founding political philosophy and also a recognition that poor blacks were both underserved by mainstream medicine and overexposed to its harms.

Nelson argues that the Party’s focus on health care was practical and ideological and that their understanding of health as a basic human right anticipated current debates about the politics of health and race.

This event is co-sponsored with Sociology and Critical Race and Ethnic Studies.

May 22, 2012 | Authority, Expertise and Power in Mexican Forests: A Discussion with Andrew Mathews

Tuesday May 22, 2012

4-6:00 PM

Engineering 2, 599

Join us for a discussion of Science & Justice member Andrew Matthew’s recently released book, Instituting Nature: Authority, Expertise and Power in Mexican Forests (MIT Press).

Greater knowledge and transparency are often promoted as the keys to solving a wide array of governance problems. In Instituting Nature, Andrew Mathews describes Mexico’s efforts over the past hundred years to manage its forests through forestry science and biodiversity conservation. He shows that transparent knowledge was produced not by official declarations or scientists’ expertise but by encounters between the relatively weak forestry bureaucracy and the indigenous people who manage and own the pine forests of Mexico. Mathews charts the performances, collusions, complicities, and evasions that characterize the forestry bureaucracy. He shows that the authority of forestry officials is undermined by the tension between local realities and national policy; officials must juggle sweeping knowledge claims and mundane concealments, ambitious regulations and routine rule breaking.
Moving from government offices in Mexico City to forests in the state of Oaxaca, Mathews describes how the science of forestry and bureaucratic practices came to Oaxaca in the 1930s and how local environmental and political contexts set the stage for local resistance. He tells how the indigenous Zapotec people learned the theory and practice of industrial forestry as employees and then put these skills to use when they become the owners and managers of the area’s pine forests–eventually incorporating forestry into their successful claims for autonomy from the state. Despite the apparently small scale and local contexts of this balancing act between the power of forestry regulations and the resistance of indigenous communities, Mathews shows that it has large implications–for how we understand the modern state, scientific knowledge, and power and for the global carbon markets for which Mexican forests might become valuable.

Andrew Mathews, "Authority, Expertise and Power in Mexican Forests"
SJWG Rapporteur Report
22 May 2012
Rapporteur: Martha Kenney, History of Consciousness
Andrew Mathews , Assistant Professor of Anthropology at UCSC, spoke to us about his new
book, Instituting Nature: Authority, Expertise and Power in Mexican Forests. Drawing on his
background in forest ecology, Mathews investigated the uses of and discourses around fire in
Mexican forests using historical, ethnographic, and scientific methods. Although pine forests
need fire for growth and regeneration, the Mexican state has demonized the use of fire,
characterizing it as destructive, catastrophic, and abnormal. For officials, who are tasked with
the responsibility of maintaining orderly landscapes, the practice of using fire to maintain the
forest seems messy and incomprehensible. Because of the dominance of this official discourse
and because of the illegality of burning many of the people Mathews spoke to claimed that fire
was not used to maintain the surrounding forests (even though there was evidence of fire
histories). Although there is an official form to apply for permission to burn, no one has ever
applied. Mathews argued that these “official channels” prevent agricultural practices from
becoming official knowledge, silences multiple knowledges, and prevents people from
understanding the agricultural uses for fire. His ethnographic work, for example, shows that the
younger generation only had negative views of fire as something that needed to be fought and
controlled. Older people, on the other hand, tended to see fire as a kind of ally in growing crops,
not a dangerous force outside of human sociality. As fire is made illegal, agricultural history is
forgotten. The government’s demands for legibility and transparency are producing doubt and
confusion. Overall, Mathews showed how looking at fire helps us to think about “The State” in
a concrete way and opens up important questions about which forest management practices can
survive and in what form.

During the Q&A Jenny Reardon asked about how Mathews’ hybrid methods articulated different
forms of evidence. Mathews said that he looked for resistances and uncertainty in his methods.
He was interested in surprise and the limits of method. Multiple knowledges destabilize each
other in productive ways. Anna Tsing picked up the question of science and justice and wanted
to know if there was such a thing as “justice for pines.” Mathews talked about the agencies of
pines and how they have memory and imagination build into their structure. Matthias wanted to
know what nations have against fire. Mathews said that the distrust of fire stems from
imaginaries of rural disorder and power of fire to transform landscapes in unpredictable ways.
Transformation is difficult for governments to deal with, since they strive to create order. These
and other questions helped to further draw out the stakes of Mathews’ project and connect them
to larger S&J questions about interdisciplinary knowledge, more-than-human justice, and the role
of discourse and state regulation in shaping technoscientific practices.

May 08, 2012 | Are You My Data? Symposium

Conference hosted by the Science & Justice Working Group Conference
sponsored by the UCSC Office of Research, and the UCSC Cancer Genomic Hub

With a human genome sequenced and a map of variable sites in that genome created, governments and many other public and private actors now seek to make genomic data relevant to health, medicine and the society. However, to do so they must navigate the conjunction of two different approaches to data. Within the biomedical domain there are important, well-articulated infrastructures and commitments arising out of concerns about individual rights, patient privacy and the doctor-patient relationship that limit access to biomedical data. This stands in stark contrast to the culture of open access forged by those who worked on the Human Genome Project, and that has continued to be a central commitment of ongoing Human Genome research. Thus, architects of the genomic revolution face competing, complex technical and ethical challenges that arise from this meeting of these domains with substantially different ethos. Additionally, the rise of social media has led to a broad and contested discussion about the proper relationship between persons and data and who profits through access to it.

Continue Reading May 08, 2012 | Are You My Data? Symposium

Mar 13, 2012 | Can Science Have Progressive Goals? A Discussion with Alondra Nelson

Tuesday, March 13, 2012
4-6:00 PM in Engineering 2, 599

Narratives of scientific progress are often paired with narratives about political progress, suggesting that the expansion of scientific knowledge always—or at least generally—leads to the betterment of humankind as a whole. But many socially disadvantaged and oppressed peoples contend that such “progress” is distributed unevenly and often comes at some cost to them. Alondra Nelson will share some of her research on Black politics and genetic genealogy to open a discussion on whether science can have progressive ends, if there can truly be a “science for the people,” and how science and justice can have paired or oppositional goals.

Herman Gray (Sociology) will be a respondent.

Alondra Nelson, "Can Science Have Progressive Goals?"
SJWG Rapporteur Report:
13 March 2012
Rapporteur: Martha Kenney, History of Consciousness
Alondra Nelson, Associate Professor of Sociology at Columbia, spoke to us about DNA testing
in African American communities. She framed her talk with articles from Nicholas Wade and
Craig Venter that argued that genomics has not lived up to its original hype. Nelson said that
despite these pronouncements there is currently a lot going in genomics outside of medicine.
She suggested that the logics of DNA analysis have made their way into our culture as social and
political technologies.

Nelson used the popularity of the genetic ancestry testing company “African Ancestry” as her
primary example. When she conducted her fieldwork, Nelson was interested in “how and why
African Americans would put their DNA in an envelope and send it to a stranger,” especially
given the vulnerability of African American communities in the history of American biomedical
institutions. She found that “African Ancestry” appealed to pre-existing genealogical
organizations, whose members were mainly middle class women, ages 50+ engaged in practices
of “kin keeping.” In this context Nelson became interested in what she calls “the social life of
DNA,” the way that DNA and genetic technologies takes on meaning in social worlds. “The
social life of DNA” serves as a reminder that genetic technologies are not only one thing (e.g.
bio-informatic technologies tied to histories of oppression) but take on different political
possibilities in different historical and social contexts.

Nelson also found that African American consumers were drawn to “African Ancestry” because
of the involvement of a scientist named Rick Kittles. Early in his career Kittles had been
instrumental in contesting how the remains in an African American burial ground in Lower
Manhattan were classified. Familiar with the racism in the history of physiology, Kittles
believed the remains should be analyzed for what he framed as their “ethnic” origins not their
race. This earned Kittles the trust of African American communities; Nelson referred to him an
“authentic expert”—someone who is seen as authentically holding African American values and
is a scientific expert by way of his training and standing in scientific communities. Her
discussion of Kittles foregrounded how authenticity and expertise make ancestry testing a viable
option for kin-making in African American communities, and how critiques of scientific racism
have shaped biological categories (e.g., the use of ethnicity instead of race) and scientific
practices of classification, creating new ways of constructing biological kinship.

In the final part of her talk, Nelson discussed how genetic technologies were being imbricated
into issues of racial slavery and cultural memory. In the case Farmer-Paellmann v. FleetBoston,
which sought reparations for descendants of slaves who were bought and sold by a private
corporation, genetic ancestry testing was used to constitute proof of slave ancestry. This
evidence did not prove substantive, however, because the court drew a distinction between
genetic and genealogical connection, arguing that the plaintiffs needed to prove the latter. The
other example raised by Nelson was the Leon H Sullivan Foundation, which has argued that
African Americans and Africans share a linked fate. In the context of genetic technologies they
have argued that African Americans should target their philanthropy to the groups they are
genetically connected to. These two cases offered examples of people enrolling genetic
technologies in their political initiatives, claiming kinship (to slaves and African communities)
that was otherwise unknown or denied to them with other kinds of evidence. Nelson ended on
these examples to bring us to her central question: “can science have progressive goals?” If
ancestry tests have been creating new kinds of kinship that can serve as a basis for forming
political identities, are there ways to develop these potentialities further and in different
directions?

Herman Gray, Professor of Sociology at UC Santa Cruz, acted as a respondent to Nelson’s talk.
He was curious about what relationships between individuals and collectives are made in the
practice of genetic ancestry tests: What kinds of imagined communities (Benedict Anderson) do
they create? How are these communities formed? And how do they foster a sense of belonging?
Gray wondered about authority and expertise in the cases laid out by Nelson: What is the
relationship between legitimization and expert knowledge? What is the nature of people’s claims
on experts? And how do people become implicated in state projects—in particular, neoliberal
ones that emphasize individual responsibility—in these configurations of science and expertise?
What kind of politics—if any—are possible in these sorts of state projects? Finally, drawing on
critical race theorist Saddiya Hartman, Gray asked what kinds of genealogical fantasies are
created through the practice of genetic ancestry testing. In Gray’s response, he expressed more
trepidation than Nelson about the political potentials of genetic testing. He felt that the desire for
ancestry testing in African American communities played into the forms of individualism
encouraged in American society and relied on outside expertise to make authoritative knowledge
claims.

In her response to Gray, Nelson emphasized that genetics is never only about the individual, but
is a basis for affiliation. She returned to Rick Kittles, whom she characterized as having a
special kind of post-Civil-Rights expertise. Nelson also took the opportunity to flesh out her
concept of “the social life of DNA,” which she defined as an analytic that understands that there
are different spheres with different stakes in genetic technologies, but they co-authorize one
another. She also emphasized that genetic ancestry testing is a kind of politics, if we are to
define politics as people trying to make change. In this way Nelson endeavored to take seriously
the political and scientific desires of the people she interviewed rather than explaining them
away as motivated by unconscious ideologies.

During the Q&A, Ed Green asked if African American consumers were satisfied with their test
results, because he did not feel he got useful ancestry information from his own genetic testing;
the time-scale was too large. Whitney Boesel followed up on this question later by asking about
the relationship between ancestry information and medical information; did people who wanted
ancestry tests also want medical information? Lisa Petrella was curious about what Nelson meant
by “progressive”--is it about political or scientific progress? Megan Moodie wondered what the
connections and disconnections between African Americans’ interest in ancestry tests and
Mormons’. Max Tabatchnik asked how African American communities understand the difference
between race and ethnicity in the context of Rick Kittles and the politics of these biological
categories in general. Continuing the theme of political possibilities, Jenny Reardon asked what
kind of stories produced something as politically “actionable” in this context. Pierre du Plasiss
and Herman Gray were curious about the difference between a politics of recognition and a
politics of representation. Through the audience questions and Alondra Nelson’s thoughtful
responses, questions of political and scientific categories, community and identity, authenticity
and expertise, arose in their specific relationships to violent histories (slavery and scientific
racism). Without answering the question “can science have progressive goals?” Nelson
presented a complex landscape where different communities have incorporated genetic
technologies into their practices of making community and telling histories. Staying true to the
political yearnings of her interview/ethnographic subject, while asking questions from critical
race theory and Science and Technology Studies, Nelson provided compelling ways to approach
the complexities of doing politics with and through emerging technologies.

Feb 06, 2012 | Cells, Race and Stories: A Discussion with Priscilla Wald about Henrietta Lacks and the HeLa Cell Line

Priscilla Wald (Duke, English and the Center for Genome Ethics, Law and Policy)

Monday, February 6, 2012

Engineering 2, 599

4:00-6:00 PM

This event is co-sponsored with Cultural Studies, Center for Biomolecular Sciences and Engineering—Research Mentoring Institute, and the Molecular, Cellular and Developmental Biology Department.

Priscilla Wald, "Cells, Race and Stories: A Discussion about Henrietta Lacks and the HeLa Cell Line"
SJWG Rapporteur Report
6 February 2012
Rapporteur: Martha Kenney, History of Consciousness
Priscilla Wald, Professor of English at Duke University, spoke to us about the ethical
implications of the Henrietta Lacks case, which has recently become widely known due to the
popularity of Rebecca Skloot’s book, The Immoral Life of Henrietta Lacks. Henrietta Lacks was
a black woman born in 1920 in Virginia, whose cancer cells were used to develop an immortal
cell line known as HeLa cells. Although these cells became important to biomedical research,
Lacks herself died of cancer on a segregated hospital ward in 1951. Neither Lacks nor her
family knew that the cells were taken from here nor did they profit from the HeLa cell line. This
case has become a touchstone for many people in thinking about bioethics in the 20th and 21st
centuries.

Wald argued that many of the stories about Lacks do not help us address key issues of science
and justice. For example, some stories center around medical wrongdoing; however, it is not
clear what the specific wrongdoing was or how it could have addressed. When accounts focus
on wrongdoing they often imply that Lacks should have been treated better because she had
“special cells.” According to Wald, these stories miss the role that institutionalized racial
inequality played in the Lacks case along with hundreds of thousands of other, less spectacular
cases.

Wald’s own approach to narrating the Henrietta Lacks is located in a tradition that focuses on
structural violence. Thinkers in this tradition map the differential effects of the power through
stratified populations, analyze the language through which these structures appear to be
unchangeable, highlight where we have the responsibility to change it, chart the continuing
abuses of structural inequality, and call for reparative measures in the present for violence of the
past. Wald wants to use this model of critique as a means to redress (which has flourished in
ethnic studies) as a model for understanding scientific change and biopolitics.

Wald believes we need to pay attention to what kinds of stories are being told about Lacks and
the HeLa cell line and think about how structural racism figures in these stories. Wald gave
examples of how, after the disclosure that the cell line was developed from Lacks’ tissue, that the
cells themselves became gendered, racialized and sexed. When it appeared that HeLa cells were
making their way into other cell lines and biological specimens in laboratories, negative
language was used to describe the situation. It was said that HeLa cells were “virulent” and
“ruined” other cell lines. Racial overtones were especially evident in a case where a white
baby’s cells were “contaminated” with HeLa cells and appearing biologically “black,” leading to
racist humor about sexual promiscuity and uncertain paternity. When HeLa cells showed up in
Russian cell lines, they were figured as out of control American agents, cellular Mata Haris.
Wald argued that these racialized stories are taking the focus off of real-world solutions to
biomedical disparity. For example, talking about the Lacks case in terms of “bioslavery,”
spectacularly summoned the past to conjure a dystopian future where our tissues were no longer
our own property. According to Wald these kind of stories deflect attention from how historical
racism is still at work in the present. She argued that we should be having a better debate about
the healthcare system rather than entertaining anxieties about a sci-fi future. Wald concluded by
arguing that we should pay attention to institutional racisms and structural violence and endeavor
to turn critique into change. We need better stories that combine this kind of critique with a
belief in new possibilities.

During the discussion audience members were interested in what Wald meant by stories and
what it means to intervene at the level of the story. Sandra Harvey, who was struck by the pain
of Lacks’ family in Skloot’s book, asked how scientists could understand their pain as a way into
the justice questions. Jake Metcalf wondered if scientists have particular justice obligations in
biomedical matters. Donna Haraway argued that scientists are more responsible because
knowledge carries obligations and stories are important because they evoke the ability to care in
thicker ways. One biologist wondered what the “take home message” of the talk was and what
he was capable of doing to promote social justice. Martha Kenney affirmed her belief in
storytelling, but wondered what other caring practices scientists and others could do alongside
telling good stories. The discussion foregrounded the complex relationship between stories,
science, and biomedical justice.

Jan 31, 2012 | Scientific Research on Ayahuasca and Health

Bia Labate

Tuesday, January 31, 2012, 4-6pm

Engineering 2, 599

Beatriz Labate has studied the scientific and social features of psychoactive substances for over 15 years. In this meeting we will discuss the situation surrounding the compound ayahuasca, a psychedelic used in both medical and spiritual contexts throughout the Americas. By exploring the frontiers and limits between “therapeutic” and “religious” uses of ayahuasca (and their complicated legal implications) we will better understand the relationship between diverse forms of knowledge production associated with what have been called “sacred technologies.”

Bia Labate, "Scientific Research on Ayahuasca and Health"
SJWG Rapporteur Report
31 January 2012
Rapporteur: Martha Kenney, History of Consciousness
Bia Labate, PhD Candiate in Social Anthropology at the University of Campinas, spoke to us
about the public debate and competing discourses around Ayahuasca, a psychoactive brew of two
plant extracts used around the world in shamanism, healing, sorcery, divination, warfare, and
hunting. Because one of the plants, psychotria viridis, contains the Schedule I narcotic DMT,
Ayahuasca (the bush, the extract from the bush, and the preparation) has been subjected to a
number of diverse regulations worldwide. Labate showed how these regulations are embedded
in different local and global discourses, producing new meanings and uses for Ayahuasca. In
Brazil it is allowed for ritual and religious use, though not therapeutic use. Whereas in Peru it is
considered the “traditional medicine of the indigenous people” and protected as cultural heritage.
In the U.S. the regulation of Ayahuasca created tensions between religious freedom and drug
laws; for the moment religious freedom has prevailed. While in France Ayahuasca was
connected to brainwashing by cults and sects, creating a total ban that includes not just the
extract but the bush as well. Through these examples, Labate showed how Ayahuasca became
entangled in discourses of religious liberty, traditional medicine, personal use, and religious
cults.

In the second half of her talk Labate discussed competing narratives of therapeutic vs. religious
use and harm vs. healing. She showed how these categories were difficult to define and took on
different contours based on national and cultural specificities. These categories raise important
and difficult questions: How do you define a religion? How do you insert traditional medicine
into a public health system? Is scientific legitimization the only route to prove therapeutic
properties? How can we define and police cultural authenticity? As different groups try to
answer these questions, Labate argues that there is a reciprocal appropriation of legal,
anthropological, biomedical discourses. For example, the anthropological category of
“ceremony” is taken up by shamans who prepare Ayahuasca. As a sacred ceremony rather than a
practice of everyday life, “the Ayahuasca ceremony” is something that can be marketed at panindigenous
festivals. Labate concluded her talk by arguing for the space of the social sciences in
this debate; she believes that if Ayahuasca is studied only in a biomedical framework that we lose
important insights into cross-pollination of discourses and identities that happens in this collision
of legal, biomedical, and religious categories.

In the Q&A members of the audience were interested in categories that betrayed the simple
equation of Ayahuasca with DMT. Andrew Matthews, drawing from his fieldwork on forestry in
Mexico, suggested that defining Ayahuasca as more than just the drug could be important for
these questions of regulation. Guillermo Delgado suggested that it was necessary to use specific
indigenous terms for Ayahuasca use rather than use anthropological or pan-indigenous terms like
“shamanism.” Martha Kenney asked if the term “sacred technology” that appeared in the
newsletter description of the talk was a useful term in Labate’s work. Craig Reinerman asked
about the value of the sociological categories of “set and setting” for understanding how “the
same drug” can have different effects in different cultures.

As Labate answered these and other questions, she provided a greater sense of the complexity of
Ayahuasca worlds. She explained, for example, how psychotria viridis was introduced to Hawaii
(and the crisis of regulation that ensued), how she tried to understanding Ayahuasca as inducing
the experience of “becoming plant,” how “shamanism” is a term that is embraced by many
indigenous Ayahuasca preparers, and how environmental regulations were taking the place of
drug regulations in some contexts. By illustrating the complexities involved in the global
understanding and regulation Ayahuasca, Labate illustrated how the skills of social scientists can
contribute to the ongoing dialogue.

Jan 26, 2012 | Eating Information? Food and Metabolism in Epigenetic Perspective

Hannah Landecker (UCLA Center for Genetics and Society)

Thursday January 26, 2012, 3:00-5:00 PM

Engineering 2, Room 399

Epigenetics has turned food and its metabolism into a problem that is not just about how the body turns food its basic components–carbohydrates, fat, protein-but how food acts as a signal of the environment–both biological and political. Hannah Landecker will explore what this transformation of metabolism and epigenetics reveals about food, environmental politics, and the increased salience of metabolism as a sight for biological understanding and political and moral contestation.

Jan 26, 2012 | Eating Information? Food and Metabolism in Epigenetic Perspective

Hannah Landecker (UCLA Center for Genetics and Society)

January 26, 2012, 3:00-5:00 PM

Engineering 2, Room 399

Epigenetics has turned food and its metabolism into a problem that is not just about how the body turns food its basic components–carbohydrates, fat, protein-but how food acts as a signal of the environment–both biological and political. Hannah Landecker will explore what this transformation of metabolism and epigenetics reveals about food, environmental politics, and the increased salience of metabolism as a sight for biological understanding and political and moral contestation.

Hannah Landecker, "Eating Information? Food and Metabolism in Epigenetic Perspective"
SJWG Rapporteur Report
26 January 2012
Rapporteur: Martha Kenney, History of Consciousness
Hannah Landecker, Associate Professor at the Society and Genetics Institute at UCLA, spoke to
us about her new book project, American Metabolism. Although the field that she is interested in
is called “nutritional epigenetics,” Landecker has reframed this research as belonging to a longer
tradition of studying “metabolism.” For Landecker, metabolism is about trans-substantiation, one
substance being changed into another. In recent nutritional epigenetics research, we see new
pathways of trans-substantiation. For example, Landecker showed us an article with a mother
mouse and her pups captioned: “They are what she ate.”

After giving us an overview of the epigenetics research, Landecker focused on the theory that
gene expression is regulated by signals from the environment, creating different phenotypes in
the presence of genetic sameness. In research on maternal anxiety behaviors, trans-generational
endocrine disruptors, and nutritional effects, we witness how licking, plastic, and food,
respectively, are presented as environmental signals. Landecker believes that the category of
“signal” is both incredibly productive and not very precise; it is under-theorized by scientists and
STS scholars. She wonders if, in the field of nutritional epigenetics, “the social” has become a
signal.

In the last part of her talk Landecker compared studies of metabolism in the late 19th century to
contemporary research in nutritional epigenetics. Early accounts of metabolism, such as those
by Thomas Huxley, figured metabolism as a set of processes the function like a factory or inner
laboratory. Landecker argued that this was an industrial paradigm for an industrial era. Key
figures and areas of emphasis were: energy, manufacturing, substrate, waste accumulation, labor
and fatigue. In the post-industrial era a new set of figures has arisen: Information, regulation,
signal (timing), functional asynchrony, sleeping and aging. She strongly believes that changes in
the framework for understanding metabolism changes what experiments are conducted and what
kind of knowledge is created. She concluded by arguing that it is important to track and
understand these changes as they are happening.

During the Q&A key questions revolved around the historical specificity of nutritional
epigenetics and issues of social and ethical responsibility arising from this new framework for
metabolism. Jake Metcalf compared responsibility in the factory model with the post-industrial
model. In the factory model, he argued, one person is responsible for the consumption of food;
in the post-industrial regulatory model, many-many humans and non-humans are responsible.
How do we delegate responsibility? Playing off of Landecker’s characterization of epigenetics
belonging to a biology of the in-between, Jenny Reardon suggests that it is difficult to regulate
the in-between. Metcalf replied that we just don’t have the models to make decision-making
viable. Landecker characterized this problem as being burdened by complexity.

This led to the question of what kind of “actionable knowledge” is created by metabolism
research and the figures that underpin it. Responding to a question by Julie Guthman about the
DES growth hormone used in cattle farming, Landecker argued that the current DES problem
was caused by the industrial model, which tried to produce as much meat possible for as little
feed as possible. In other words, the metaphors of a previous generation of science created the
material conditions of today’s farming.

The remaining questions continued to play about this interrelationship between metaphor and
materiality. Elaine Gan, for example, suggested that we think about metabolism metaphors in
Marx. Landecker explained that these were not only metaphors; Marx was deeply interested in
the science of metabolism and believed, for example, that the Irish peasants would not revolt
because they lived off of potatoes. This rich discussion foregrounded the importance of tracking
the relationship between figures, history, materiality, knowledge, and production when
considering questions of science and justice in hot new scientific fields like epigenetics.